Skip to main content
SpringerLink
Log in
Book cover

Lipoxygenases and their Metabolites pp 199–209Cite as

Fatty Acids, Eicosanoids, and Hypolipidemic Agents Regulate Gene Expression Through Direct Binding to Peroxisome Proliferator-Activated Receptors

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 447))

Abstract

Maintenance of caloric homeostasis is a vital function that depends on a fine-tuned regulation of fuel uptake, storage and utilisation in response to both environmental conditions and internal stimuli. The control machinery includes, among others, factors that transduce metabolic parameters into gene regulatory events. The characterisation of such factors highly contributes to the elucidation of the molecular basis of energy balance and to our understanding of associated disorders.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams M, Reginato MJ, Shoa D, Lazar MA and Chatterjee VK. (1997) Transcriptional activation by peroxisome proliferator-activated receptor y is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site, J. Biol. Chem. 272, 5128–5132.

    Article  PubMed  CAS  Google Scholar 

  • Braissant O, Foufelle F, Scotto C, Dauça M and Wahli W. (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR alpha, beta and gamma in the adult rat, Endocrinology 137, 354–366.

    Article  PubMed  CAS  Google Scholar 

  • Brock TG, McNish RW, Bailie MB and Peters-Golden M. (1997) Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence, J. Biol. Chem. 272, 8276–8280.

    Article  PubMed  CAS  Google Scholar 

  • Brun RP, Kim JB, Hu E, Altiok S and Spiegelman BM. (1996a) Adipocyte differentiation: a transcriptional regulatory cascade, Current Opinion in Cell Biology 8, 826–832.

    Article  PubMed  CAS  Google Scholar 

  • Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM and Spiegelman BM. (1996b) Differential activation of adipogenesis by multiple PPAR isoforms, Genes Dev. 10, 974–984.

    Article  PubMed  CAS  Google Scholar 

  • Camp HS and Tafuri SR. (1996) Regulation of peroxisome proliferator-activated receptor γ activity by mitogenactivated protein kinase, J. Biol. Chem. 272, 10811–10816.

    Google Scholar 

  • Canan Koch SS, Dardashti LJ, Hebert JJ, White SK, Croston GEF, Flatten KS, Heyman RA, and Nadzan AM. (1996) Identification of the First Retinoid X Receptor Homodimer Antagonist, J. Med. Chem. 39, 3229–3234.

    Article  PubMed  CAS  Google Scholar 

  • Desvergne B and Wahli W. (1995) PPAR: a key nuclear factor in nutrient/gene interaction? In: Inducible gene expression, PA Baeuerle ed, Birkhäuser, Boston, Vol 1, pp. 142–176.

    Google Scholar 

  • Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ and Wahli W (1996) The PPARa-leukotriene B4 pathway to inflammation control, Nature 384, 39–43.

    Article  PubMed  CAS  Google Scholar 

  • Devchand PR and Wahli W. (1997) PPARa: Tempting fate with fat, In: Hormones and Signalling BW O’Malley ed, Academic Press, San Diego, Vol 1 in press.

    Google Scholar 

  • Dreyer C, Krey G, Keller H, Givel F, Helftenbein G and Wahli W. (1992) Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors, Cell 68, 879–87.

    Article  PubMed  CAS  Google Scholar 

  • Dowell P, Peterson VJ, Zabriskie TM and Leid M. (1997) Ligand-induced peroxisome proliferator-activated receptor a conformational change, J. Biol. Chem. 272, 2013–2020.

    Article  PubMed  CAS  Google Scholar 

  • Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM and Evans RM. (1995) 15-deoxy-delta(12,14)-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR-gamma, Cell 83, 803–12.

    Article  PubMed  CAS  Google Scholar 

  • Forman BM, ChenZ J and Evans RM. (1997) Hypolipidemic drugs, polyunsaturated fatty acids and eicosanoids are ligands for PPARa and PPARγ, Proc. Natl. Acad. Sci. USA 94, 4312–4317.

    Article  PubMed  CAS  Google Scholar 

  • Gearing KL, Göttlicher M, Teboul M, Widmark E and Gustafsson JÅ. (1993) Interaction of the peroxisome proliferator-activated receptor and retinoid X receptor, Proc. Natl. Acad. Sci. USA 90, 1440–1444.

    Article  PubMed  CAS  Google Scholar 

  • Göttlicher M, Widmark E, Li Q and Gustafsson JÅ. (1992) Fatty acids activate a chimera of the clofic acid-activated receptor and the glucocorticoid receptor, Proc. Natl. Acad. Sci. USA 89, 4653–4657.

    Article  PubMed  Google Scholar 

  • Hu ED, Tontonoz P and Spiegelman BM. (1995) Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR-gamma and C/EBP-alpha, Proc. Natl. Acad. Sci. USA 92, 9856–9860.

    Article  PubMed  CAS  Google Scholar 

  • Hu E, Kim JB, Sarraf P and Spiegelman BM. (1996) Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARy, Science 274, 2100–2103.

    Article  PubMed  CAS  Google Scholar 

  • Issemann I and Green S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators, Nature 347, 645–650.

    Article  PubMed  CAS  Google Scholar 

  • IJpenberg A, Jeannin E, Wahli W and Desvergne B. (1997) Polarity and specific sequence requirements of PPARRXR heterodimer binding to DNA: A functional analysis of the malic enzyme gene PPRE, J. Biol. Chem., 272, 20108–20117.

    Article  Google Scholar 

  • Juge-Aubry C, Pernin A, Favez T, Burger AG, Wahli, W, Meier CA and Desvergne B. (1998) DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements: importance of the 5′ flanking region, J. Biol. Chem.. 272, 25252–25259.

    Article  Google Scholar 

  • Keller H, Dreyer C, Medin J, Mahfoudi A, Ozato K and Wahli W. (1993) Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers, Proc. Natl. Acad. Sci. USA 90, 2160–2164.

    Article  PubMed  CAS  Google Scholar 

  • Keller H, Devchand PR, Perroud M and Wahli W. (1997) PPARα structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents, Biol. Chem., 378, 651–655.

    Article  PubMed  CAS  Google Scholar 

  • Kliewer SA, Umesono K, Noonan DJ, Heyman RA and Evans RM. (1992) Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors, Nature 358, 771–774.

    Article  PubMed  CAS  Google Scholar 

  • Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC and Lehmann JM. (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation, Cell 83, 813–819.

    Article  PubMed  CAS  Google Scholar 

  • Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS Devchand P, Wahli W, Willson TM, Lenhard JM and Lehmann JM. (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ, Proc. Natl. Acad. Sci. USA 94, 4318–4323.

    Article  PubMed  CAS  Google Scholar 

  • Krey G, Braissant O, L’Horset F, Kalkhoven E, Perroud M, Parker MG and Wahli, W. (1997) Fatty acids, ei-cosanoids and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by CARLA, Mol. Endocrinol 11, 779–791.

    Article  PubMed  CAS  Google Scholar 

  • Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H and Gonzalez FJ. (1995) Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators, Mol. Cell Biol. 15, 3012–3022.

    PubMed  CAS  Google Scholar 

  • Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM and Kliewer SA. (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma), J. Biol. Chem. 270, 12953–12956.

    Article  PubMed  CAS  Google Scholar 

  • Lemberger T, Desvergne B and Wahli W. (1996a). Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology, Annu. Rev. Cell Dev. Biol. 12, 335–363.

    Article  PubMed  CAS  Google Scholar 

  • Lemberger T, Saladin R, Vazquez M, Assimacopoulos F, Staels B, Desvergne B, Wahli W and Auwerx J. (1996b) Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm, J. Biol. Chem. 271, 1764–1769.

    Article  PubMed  CAS  Google Scholar 

  • Lemberger T, Staels B, Saladin R, Desvergne B, Auwerx J and Wahli W. (1994) Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids, J. Biol. Chem. 269, 24527–24530.

    PubMed  CAS  Google Scholar 

  • Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM and Kliewer SA. (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma), J. Biol Chem. 270, 12953–12956.

    Article  PubMed  CAS  Google Scholar 

  • Mukherjee R, Davies PJA, Crombie DL, Bischoff ED, Cesarie RM, Jow L, Hamann LG, Boehm MF, Mondon CE, Nadzan AM, Paterniti JR Jr. and Heyman RA. (1997) Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists, Nature 386, 407–410.

    Article  PubMed  CAS  Google Scholar 

  • Schulman IG, Li C, Schwabe JWR and Evans RM. (1997) The phantom ligand effect: allosteric control of transcription by the retinoid X receptor, Genes Dev. 11, 299–308.

    Article  PubMed  CAS  Google Scholar 

  • Serhan C. (1996) Signalling the fat controller, Nature 384, 23–24.

    Article  PubMed  CAS  Google Scholar 

  • Shalev A, Siegrist-Kaiser CA, Yen PM, Wahli W, Burger AG, Chin WW and Meier CA. (1996) The peroxisome proliferator-activated receptor a is a phosphoprotein: regulation by insulin, Endocrinology 137, 4499–4502.

    Article  PubMed  CAS  Google Scholar 

  • Tontonoz P, Hu E, Graves RA, Budavari AI and Spiegelman BM. (1994) mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer, Genes Dev. 8, 1224–1234.

    Article  PubMed  CAS  Google Scholar 

  • Vidal-Puig AJ, Considine RV, Jimenez-Linan M, Werman A, Pories WJ, Caro JF and Flier JS. (1997) Peroxisome proliferator-activated receptor gene expression in human tissues, J. Clin. Invest. 99, 2416–2422.

    Article  PubMed  CAS  Google Scholar 

  • Willson TM and Wahli W. (1997) Peroxisome Proliferator-Activated Receptor (PPAR) agonists, C0urrent Opinion in Chemical Biology, 1, 235–241.

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Walter Wahli

    Present address: Institut de Biologie animale Faculté des Sciences, Université de Lausanne, Bâtiment de Biologie, CH-1015, Lausanne, Switzerland

Authors and Affiliations

  1. Institut de Biologie animale, Université de Lausanne, Bâtiment de Biologie, CH-1015, Lausanne, Switzerland

    Walter Wahli, Pallavi R. Devchand, Annemieke I. Jpenberg & Béatrice Desvergne

Authors
  1. Walter Wahli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pallavi R. Devchand
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Annemieke I. Jpenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Béatrice Desvergne
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Free University of Berlin, Berlin, Germany

    Santosh Nigam

  2. Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

    Cecil R. Pace-Asciak

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Kluwer Academic/Plenum Publishers, New York

About this chapter

Cite this chapter

Wahli, W., Devchand, P.R., Jpenberg, A.I., Desvergne, B. (1999). Fatty Acids, Eicosanoids, and Hypolipidemic Agents Regulate Gene Expression Through Direct Binding to Peroxisome Proliferator-Activated Receptors. In: Nigam, S., Pace-Asciak, C.R. (eds) Lipoxygenases and their Metabolites. Advances in Experimental Medicine and Biology, vol 447. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4861-4_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-4861-4_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46044-9

  • Online ISBN: 978-1-4615-4861-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation