Regular ArticleEffect of Linoleic Acid Metabolites on Na+/K+ Pump Current in N20.1 Oligodendrocytes: Role of Membrane Fluidity
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Metabolomics reveals increased isoleukotoxin diol (12,13-DHOME) in human plasma after acute intralipid infusion
2012, Journal of Lipid ResearchCitation Excerpt :Thus, inhibition of sEH ameliorates many of the toxic effects of the leukotoxins (39), whereas 12,13-DHOME adversely affects the electrophysiology of cells including oligodendrocytes (40) and cardiac myocytes (41). In addition, both 12(13)- and 9(10)-EpOME can be metabolized to the THF-diols (Fig. 2), themselves (together with the leukotoxin diols) capable of acting as endocrine disruptors in rats (42, 43). Given that a compromised immune system is a significant adverse effect of Intralipid infusion, particularly for the very young and the critically ill, both of whom receive Intralipid infusions and both of whom are especially vulnerable to infections, much interest is focused on potential mechanisms and appropriate prevention.
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