Regular ArticleP-Glycoprotein Deficiency in a Subpopulation of CF-1 Mice Enhances Avermectin-Induced Neurotoxicity☆
References (28)
- et al.
Targeted disruption of the mousemdr1bmdr
J. Biol. Chem.
(1993) The cell biology of multiple drug resistance
Biochem. Pharmacol.
(1987)- et al.
Internal duplication and homology with bacterial transport proteins in themdr1
Cell
(1986) - et al.
Ivermectin for spasticity in spinal-cord injury
Lancet
(1994) - et al.
Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins
Cell
(1986) - et al.
MDR expression in normal tissues—Pharmacological implications for the clinical use of P-glycoprotein inhibitors
Hematol. Oncol. Clin. NA
(1995) - et al.
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood–brain barrier and to increased sensitivity to drugs
Cell
(1994) - et al.
Avermectins. Structure determination
J. Am. Chem. Soc.
(1981) - et al.
The mechanism of action of avermectins inCaenorhabditis elegans:
J. Parasitol.
(1995) - et al.
Energy-dependent reduced drug binding as a mechanism of vinca alkaloid resistance in leukemic lymphoblasts
Mol. Pharmacol.
(1983)
Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells
Structure and expression of the humanMDR
Mol. Cell. Biol.
Metabolism and tissue residues
Ivermectin and Abamectin
Cited by (192)
Neurovascular development
2023, Encyclopedia of Child and Adolescent Health, First EditionRoutine Repeat CT Head Does Not Change Management in Trauma Patients on Novel Anticoagulants
2020, Journal of Surgical ResearchA perspective on the discovery of selected compounds with anthelmintic activity against the barber's pole worm—Where to from here?
2020, Advances in ParasitologyCitation Excerpt :By targeting the ion channels, macrocyclic lactones increase membrane permeability to chloride ions, leading to reduced pharyngeal pumping, paralysis of body muscles, and having adverse effects on the uterus (Geary et al., 1993; Gill et al., 1991; Sargison, 2012; Sutherland and Campbell, 1990; Yates et al., 2003). Macrocyclic lactones exhibit a rather selective toxicity in nematodes, presumably due to cell-membrane efflux pumps, in particular the P-glycoproteins (Broeks et al., 1995), which can exclude macrocyclic lactone drugs from distributing into the central nervous system (Kerboeuf et al., 2003; Lankas et al., 1997; McKellar and Jackson, 2004). There are studies showing that P-glycoprotein inhibitors can improve the efficacy of macrocyclic lactones through oral absorption, because P-glycoproteins are also present in the gut (Lifschitz et al., 2002; McKellar and Jackson, 2004).
Anthelmintic drugs used in equine species
2018, Veterinary ParasitologyImpact of endotoxin on the expression of drug transporters in the placenta of HIV-1 transgenic (HIV-Tg) rats
2017, European Journal of Pharmaceutical SciencesCitation Excerpt :It has been reported that several HIV viral proteins including gp120, tat and nef are capable of activating lymphocytes and macrophages, causing the release of pro-inflammatory cytokines IL-6 and TNF-α (Lee et al., 2003; Swingler et al., 2003; Appay and Sauce, 2008; Yim et al., 2009; Mogensen et al., 2010). Altered expression of placental drug transporters has been linked to higher transplacental passage, as well as drug-induced birth defects in rodents (Lankas et al., 1997; Smit et al., 1999; Choo et al., 2000; Pavek et al., 2003). Given the high incidence of subclinical endotoxemia in HIV infected individuals, our objective was to examine the impact of low-dose endotoxin on the expression of placental drug transporters in a pregnant HIV-Tg rat model.
- ☆
W. C. Campbell, Ed.