Biochemical and Biophysical Research Communications
Regular ArticleHistamine H2 Receptor Mediated Dual Signaling: Mapping of Structural Requirements Using β2 Adrenergic Chimeric Receptors
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Evidence for ligand-specific conformations of the histamine H <inf>2</inf>-receptor in human eosinophils and neutrophils
2012, Biochemical PharmacologyCitation Excerpt :Activation of H2R leads to adenylyl cyclase activation and elevation of intracellular cAMP concentration [29–31]. Furthermore, an additional Gq-protein-mediated pathway has been described [32,33]. Numerous compounds which agonize or antagonize the H2R have been synthesized [34] and H2R antagonists are used for the treatment of acid-related gastrointestinal diseases [35].
Regulation of phospholipase C activation by the number of H<inf>2</inf> receptors during Ca<sup>2+</sup>-induced differentiation of mouse keratinocytes
2002, Biochemical PharmacologyCitation Excerpt :Histamine-mediated activation of the H2 receptor subtype, in particular, can result in the activation of both adenylyl cyclase and PLC second messenger systems [15]. The structural components of the human H2 receptor required to activate adenylyl cyclase and PLC systems have been elucidated recently, but the physiological significance of H2 receptor coupling to PLC activation has not been totally clarified [38]. However, several reports have suggested that the H2 receptor-mediated activation of PLC and intracellular calcium mobilization could influence cell proliferation [39,40].
Trafficking and phosphorylation dynamics of AQP4 in histamine-treated human gastric cells
2007, Biology of the CellProbing receptor structure/function with chimeric G-protein-coupled receptors
2004, Molecular PharmacologyHistamine genomics in silico: polymorphisms of the human genes involved in the synthesis, action and degradation of histamine
2002, American journal of pharmacogenomics : genomics-related research in drug development and clinical practice
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