Biochemical and Biophysical Research Communications
Regular ArticleUrotensin II Is the Endogenous Ligand of a G-Protein-Coupled Orphan Receptor, SENR (GPR14)☆
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Identification and signaling characterization of four urotensin II receptor subtypes in the western clawed frog, Xenopus tropicalis
2020, General and Comparative EndocrinologyCitation Excerpt :Previous studies on the signaling cascade via a single UTR (UTR1) in mammals showed that UTR1 is linked to three G proteins (Gq, Gi/o, and G12/13) in various tissues and cells. UTR was originally found to primarily activate the phospholipase C (PLC)/ protein kinase C (PKC) pathway, coupled to Gq protein (Filipeanu et al., 2002; Mori et al., 1999; Nothacker et al., 1999). UTR activation with UII increases phosphoinositide turnover and induces mobilization of Ca2+ from intracellular stores (Song et al., 2006; Filipeanu et al., 2002; Gibson et al., 1988).
Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats
2016, PeptidesCitation Excerpt :Latest studies demonstrated that U-II modulates its effects via U-II receptors also known as GPR14 that are G-protein coupled receptors on cell membrane [5]. UTR was discovered by 4 groups simultaneously [9–11]. Studies showed widespread expression of U-II receptors in cardiovascular, pulmonary, central nervous, renal and metabolic systems and especially in inflammatory regions [12–14].
Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors
2014, Molecular Phylogenetics and Evolution
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Abbreviations used: UII, urotensin II; SENR, sensory epithelium neuropeptide-like receptor; EC50, median effective concentration; GPCR, G-protein-coupled receptor; TFA, trifluoroacetic acid.
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