Regular ArticleEvidence for the Presence of a Functional Pregnane X Receptor Response Element in the CYP3A7 Promoter Gene
References (20)
- et al.
Biochem. Biophys. Res. Commun.
(1985) - et al.
Biochim. Biophys. Acta
(1992) - et al.
Biochem. Biophys. Res. Commun.
(1996) - et al.
Biochem. Biophys. Res. Commun.
(1994) - et al.
Cell
(1998) - et al.
Mol. Pharmacol.
(1994) - et al.
J. Clin. Invest.
(1993) - et al.
Br. J. Clin. Pharmacol.
(1996)
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Female-specific activation of pregnane X receptor mediates sex difference in fetal hepatotoxicity by prenatal monocrotaline exposure
2020, Toxicology and Applied PharmacologyNeonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism
2019, Archives of Biochemistry and BiophysicsCitation Excerpt :Two kinds of ER6 elements [ER6-JMP (TTAACTcaatggAGGTCA) [174] and ER6-Itoh (TTAACTcaatggAGG-CA) [174,175] have been reported, which differ in only one base at the 3’ half site. The PXR:RXR complex can bind ER6-JMP but not ER6-Itoh [174,175], and the binding has been regarded as the mechanism underlying CYP3A7 expression [47]. This suggests a possible polymorphism of CYP3A7-ER6 responsiveness to activators.
Laminin-511 and laminin-521-based matrices for efficient hepatic specification of human pluripotent stem cells
2016, BiomaterialsCitation Excerpt :We determined the expression of nuclear receptors NR3C1 (also known as glucocorticoid receptor, GR), NR1I2 (also known as pregnane X receptor, PXR), and aryl hydrocarbon receptor (AhR). NR3C1 and NR1I2 mediate the induction of CYP3A [32–36]. AhR mediates the induction of CYP1A and CYP1B1 [37].
Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor
2011, Toxicology LettersCitation Excerpt :The results (Supplementary Material Table S1) showed significant (p < 0.05) and at least a two-fold difference in the expression level of more than 1000 genes. As seen in Table 2, aflatoxin B1-treated HepG2 cells showed a significant effect for expression of numerous genes coding for phase I and phase II enzymes important for xenobiotic metabolism and disposition, including genes such as CYP2R1, CYP3A5, CYP3A7 and CYP4F2 and that similarly to CYP3A4, are regulated by PXR (Burk et al., 2004; Ellfolk et al., 2009; Pascussi et al., 1999; Siest et al., 2008). Gene ontology analysis showed that, in addition to genes associated with xenobiotic catabolism, aflatoxin B1 treatment influenced multiple genes linked to lipid metabolism (Tables 2 and 3), zinc homeostasis (e.g., metallothioneins and SLC30A1), cadmium and copper ion binding (e.g., LOX and LOXL1), and insulin growth factor-mediated signaling (e.g., IGFALS, IGFBP1) (Supplementary Material Tables S1 and S2).
Interplay between cholesterol and drug metabolism
2011, Biochimica et Biophysica Acta - Proteins and ProteomicsConvergence of Multiple Nuclear Receptor Signaling
2010, Comprehensive Toxicology: Second Edition
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