Regular ArticlecDNA Cloning and Expression of Two New Members of the Human Liver UDP-Glucuronosyltransferase 2B Subfamily
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Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping
2021, Pharmacology and TherapeuticsCitation Excerpt :Moreover, of the enzymes screened, atractylenolide I additionally inhibited UGT1A3, UGT1A6 and UGT1A9 to an appreciable (~ 20–50%) extent. When first cloned, UGT2B10 was considered an orphan enzyme because it lacked activity towards the –OH and –CO2H containing aglycones typically employed for the screening of enzyme activity at that time (Jin, Miners, Lillywhite, & Mackenzie, 1993b). However, subsequent studies demonstrated that, like UGT1A4, UGT2B10 preferentially catalyses the N-glucuronidation of compounds that incorporate a tertiary amine or aromatic N-heterocyclic group (Kaivosaari et al., 2011; Kerdpin et al., 2009; Milani et al., 2020; Pattanawongsa et al., 2016).
UDP-Glycosyltransferases
2018, Comprehensive Toxicology: Third EditionMolecular reproductive characteristics of the reef coral Pocillopora damicornis
2015, Comparative Biochemistry and Physiology -Part A : Molecular and Integrative PhysiologyA comprehensive review of UDP-glucuronosyltransferase and esterases for drug development
2015, Drug Metabolism and PharmacokineticsCitation Excerpt :UGT2B11: UGT2B11 mRNA has been detected in the liver, kidney, and breast [14]; however, its quantitative evaluation at the protein level has not yet been conducted, probably because its role in drug metabolisms is unknown (Tables 1 and 2). UGT2B11 catalyzes the glucuronidation of 3α-hydroxyandrogens, 3α-pregnanes, and hydroxyestrogens [162,164], but its activities were generally lower than those of UGT2B7, suggesting that UGT2B11 is unlikely to play an important role in the metabolism of these substrates. Currently, no drugs are known to be substrates or inhibitors of UGT2B11.
UDP-Glucuronosyltransferases
2010, Comprehensive Toxicology, Second Edition