Regular ArticlecDNA Cloning and Expression of Two New Members of the Human Liver UDP-Glucuronosyltransferase 2B Subfamily
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UDP-Glycosyltransferases
2018, Comprehensive Toxicology: Third EditionMolecular reproductive characteristics of the reef coral Pocillopora damicornis
2015, Comparative Biochemistry and Physiology -Part A : Molecular and Integrative PhysiologyCitation Excerpt :The results from the current study over two consecutive lunar cycles, confirm previous findings in our laboratory, and suggest that the regulation of this enzyme is linked to the reproductive cycle of the coral (Rougee et al., in press). The UGT superfamily is variously responsible for glucuronidation of toxicants (Bock and Schirmer, 1987; Jin et al., 1993; Orzechowski et al., 1994) as well as endogenous ligands and steroid hormones (Bélanger et al., 1998; Hum et al., 1999). Regulation of this pathway can play a role in the predisposition to toxicity.
A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development
2015, Drug Metabolism and PharmacokineticsCitation Excerpt :High concentrations (2.5 mM) of fluconazole inhibit the enzyme activity of UGT2B7 by approximately 70% in vitro, although this concentration of fluconazole inhibits the activity of UGT1A1, UGT1A6 and UGT2B15 by 25% [83] and 0.22 mM fluconazole inhibits the activity of not only UGT2B7 but also UGT2B4 [87]. UGT2B10: UGT2B10 had been regarded as “an orphan UGT” whose substrates were unknown [162]. Recent studies, however, found that UGT2B10 has the ability to catalyze the N-glucuronidation of tertiary amines such as S-nicotine [163] (Kaivosaari et al., 2007).
UDP-Glucuronosyltransferases
2010, Comprehensive Toxicology, Second Edition