Regular ArticleAryl Hydrocarbon Receptor-Inducible or Constitutive Expression of Human UDP Glucuronosyltransferase UGT1A6
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Aryl hydrocarbon receptor (AHR) functions: Balancing opposing processes including inflammatory reactions
2020, Biochemical PharmacologyCitation Excerpt :When exposed to oral BaP all CYP1A1-deficient mice died from bone marrow dysplasia whereas wild-type mice survived due to efficient first-pass detoxification of BaP [8,26]. BaP detoxification in the intestinal mucosa includes tight coupling of CYP1A1-mediated BaP oxidation with conjugation by AHR-induced GSTA1/2 [27] and UGT1A6 [28], and probably all UGT1 enzymes [29] as well as transport of conjugates by AHR-induced ABCG2 [30]. For example, oxidative stress producing BaP quinones are rapidly reduced to quinoles by NQO1 (NADPH quinone oxidoreductase 1) [27] and conjugated by UGT1 enzymes [31].
UDP-Glycosyltransferases
2018, Comprehensive Toxicology: Third EditionA comprehensive review of UDP-glucuronosyltransferase and esterases for drug development
2015, Drug Metabolism and PharmacokineticsCitation Excerpt :Overall, bile acids facilitate their own inactivation by the direct activation of FXR and PXR or FXR-mediated indirect activation of PXR and PPARα. AhR induces UGT1A1 [53], UGT1A3 [54], UGT1A4 [55], UGT1A6 [56], UGT1A8, UGT1A9, and UGT1A10 [57]. The AhR binding site is conserved in all UGT1A genes [58].
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