Research ArticlesPreliminary evaluation of furosemide–probenecid interaction in humans
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Renal drug transporters and their significance in drug-drug interactions
2016, Acta Pharmaceutica Sinica BCitation Excerpt :In the following section, we highlight the importance of renal OC and OA drug transporters in mediating clinically significant DDIs. The relevant consequences on pharmacokinetics, pharmacodynamics, and drug-induced nephrotoxicity are illustrated using several well-studied clinical DDI examples as summarized in Table 114,76,81–90. hOCT2 and hMATE1/2-K form a major pathway for renal elimination of small hydrophilic drugs carrying a positive charge.
Probenecid: Novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation
2012, Journal of Molecular and Cellular CardiologyCitation Excerpt :The authors attributed the observed diuresis only to the renal aspect of probenecid and not to a potential cardiac effect. We scoured the literature, including the original FDA submissions for probenecid approval and found no other references or comments reporting an increase in diuresis specifically relating to probenecid (though several did report on its interactions with other diuretics) [58]. The occasional studies that refer to cardiac issues and probenecid are limited to its use in inflammation and infection but not direct effects on cardiac function [12].
Pharmacokinetics of Furosemide in Endolymph
1993, Auris Nasus LarynxSimultaneous determination of ketoprofen enantiomers and probenecid in plasma and urine by high-performance liquid chromatography
1991, Journal of Chromatography B: Biomedical Sciences and Applications
Supported in part by National Institutes of Health Grant AM 20884
D. E. Smith was supported as a National Institutes of Health Pre-doctoral Scholar on Training Grant GM 07175.