Research ArticlesEffect of Altered Plasma Protein Binding on Apparent Volume of Distribution
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Predicting unpredictable human pharmacokinetics: case studies from the trenches of drug discovery
2023, Overcoming Obstacles in Drug Discovery and Development: Surmounting the Insurmountable-Case Studies for Critical ThinkingEvaluation of Prediction Accuracy for Volume of Distribution in Rat and Human Using In Vitro, In Vivo, PBPK and QSAR Methods
2021, Journal of Pharmaceutical SciencesCitation Excerpt :There are at least 24 different methods available to predict human Vss with various degrees of success.3,6–12 A few examples of these methods are: single species scaling,6,13 allometric scaling,6 equivalency approaches,9 Øie-Tozer methods,6,14–16 physicochemical methods,17–20 computational models21–29 and PBPK (physiologically based PK) tissue-composition-based methods.30–36 Many comparison studies have been conducted by various groups to examine Vss prediction accuracy of the different methods.6,7,9,12
Compartmental analysis of drug distribution
2021, Atkinson's Principles of Clinical PharmacologyADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective
2021, Haschek and Rousseaux's Handbook of Toxicologic Pathology: Volume 1: Principles and Practice of Toxicologic Pathology
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