Research Articles
Effect of Altered Plasma Protein Binding on Apparent Volume of Distribution

https://doi.org/10.1002/jps.2600680948Get rights and content

First page preview

First page preview
Click to open first page preview

References (0)

Cited by (246)

  • Predicting unpredictable human pharmacokinetics: case studies from the trenches of drug discovery

    2023, Overcoming Obstacles in Drug Discovery and Development: Surmounting the Insurmountable-Case Studies for Critical Thinking
  • Evaluation of Prediction Accuracy for Volume of Distribution in Rat and Human Using In Vitro, In Vivo, PBPK and QSAR Methods

    2021, Journal of Pharmaceutical Sciences
    Citation Excerpt :

    There are at least 24 different methods available to predict human Vss with various degrees of success.3,6–12 A few examples of these methods are: single species scaling,6,13 allometric scaling,6 equivalency approaches,9 Øie-Tozer methods,6,14–16 physicochemical methods,17–20 computational models21–29 and PBPK (physiologically based PK) tissue-composition-based methods.30–36 Many comparison studies have been conducted by various groups to examine Vss prediction accuracy of the different methods.6,7,9,12

  • Compartmental analysis of drug distribution

    2021, Atkinson's Principles of Clinical Pharmacology
  • ADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective

    2021, Haschek and Rousseaux's Handbook of Toxicologic Pathology: Volume 1: Principles and Practice of Toxicologic Pathology
View all citing articles on Scopus
View full text