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Journal of Pharmacology and Experimental Therapeutics

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pharmacokinetics

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    Understanding exposure-receptor occupancy relationships for metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators across a range of pre-clinical and clinical studies
    Kirstie A Bennett, Eugenia Sergeev, Cliona P MacSweeney, Geor Bakker and Anne E Cooper
    Journal of Pharmacology and Experimental Therapeutics February 4, 2021, JPET-AR-2020-000371; DOI: https://doi.org/10.1124/jpet.120.000371
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    OATP1B1/1B3-mediated hepatic uptake determines the pharmacokinetics of large lipophilic acids: In vitro-in vivo evaluation in cynomolgus monkey
    Heather Eng, Yi-an Bi, Mark A. West, Sangwoo Ryu, Emi Yamaguchi, Rachel E. Kosa, David A. Tess, David A. Griffith, John E. Litchfield, Amit S. Kalgutkar and Manthena V. S. Varma
    Journal of Pharmacology and Experimental Therapeutics January 28, 2021, JPET-AR-2020-000457; DOI: https://doi.org/10.1124/jpet.120.000457
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    Safety, Pharmacokinetic and Pharmacodynamic Evaluation of a 2'-MOE Antisense Oligonucleotide-GalNAc3 Conjugate that Targets the Human Transmembrane Protease Serine 6 (TMPRSS6)
    Thomas A Zanardi, Birgit Korbmacher, Laura Boone, Jeffrey A Engelhardt, Yanfeng Wang, Sebastien Burel, Bobby Prill, Mariam Aghajan, Shuling Guo and Scott P Henry
    Journal of Pharmacology and Experimental Therapeutics January 11, 2021, JPET-AR-2020-000222; DOI: https://doi.org/10.1124/jpet.120.000222
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ASPET's Other Journals

  • Drug Metabolism and Disposition
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ISSN 1521-0103 (Online)

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