pharmacokinetics

You have access
Understanding exposure-receptor occupancy relationships for metabotropic glutamate receptor 5 (mGlu₅) negative allosteric modulators across a range of pre-clinical and clinical studies
Kirstie A Bennett, Eugenia Sergeev, Cliona P MacSweeney, Geor Bakker and Anne E Cooper

Journal of Pharmacology and Experimental Therapeutics February 4, 2021, JPET-AR-2020-000371; DOI: https://doi.org/10.1124/jpet.120.000371
You have access
OATP1B1/1B3-mediated hepatic uptake determines the pharmacokinetics of large lipophilic acids: In vitro-in vivo evaluation in cynomolgus monkey
Heather Eng, Yi-an Bi, Mark A. West, Sangwoo Ryu, Emi Yamaguchi, Rachel E. Kosa, David A. Tess, David A. Griffith, John E. Litchfield, Amit S. Kalgutkar and Manthena V. S. Varma

Journal of Pharmacology and Experimental Therapeutics January 28, 2021, JPET-AR-2020-000457; DOI: https://doi.org/10.1124/jpet.120.000457
You have access
Safety, Pharmacokinetic and Pharmacodynamic Evaluation of a 2'-MOE Antisense Oligonucleotide-GalNAc3 Conjugate that Targets the Human Transmembrane Protease Serine 6 (TMPRSS6)
Thomas A Zanardi, Birgit Korbmacher, Laura Boone, Jeffrey A Engelhardt, Yanfeng Wang, Sebastien Burel, Bobby Prill, Mariam Aghajan, Shuling Guo and Scott P Henry

Journal of Pharmacology and Experimental Therapeutics January 11, 2021, JPET-AR-2020-000222; DOI: https://doi.org/10.1124/jpet.120.000222

Main menu