TABLE 1

Percentage recovery (mean ± S.D., n = 4/group) of the 4-methylumbelliferone dose (30 μmol) in bile and perfusate as 4MUG and 4MUS at the end of the IPL experiment



Wild-Type Wistar Rat IPLs
Control
GF120918

Bile
Perfusate
Total
Bile
Perfusate
Total
% %
4MUG 83 ± 10 15 ± 1 98 ± 9 82 ± 8 15 ± 6 96 ± 8
4MUS 1.3 ± 0.1 4 ± 1 5 ± 1 0.6 ± 0.1 3.2 ± 0.8 3.7 ± 0.8
Total recovery
85 ± 10
18 ± 2
103 ± 9
82 ± 8
18 ± 6
100 ± 9
Mrp2-Deficient TR- Rat IPLs
Control
GF120918

Bile
Perfusate
Total
Bile
Perfusate
Total
% %
4MUG 1.2 ± 0.3* 91 ± 9* 92 ± 9 0.5 ± 0.3* 80 ± 9* 81 ± 9*
4MUS 0.50 ± 0.03* 6.7 ± 0.2* 7.2 ± 0.2* 0.04 ± 0.03* 7.1 ± 0.6* 7.2 ± 0.6*
Total recovery
1.7 ± 0.4*
97 ± 9*
99 ± 9
0.5 ± 0.4*
88 ± 9*
88 ± 8
  • * p < 0.05, TR- vs. Wild Type within GF120918 treatment group

  • p < 0.05, GF120918 vs. Control within rat group