TABLE 4

Relative ratio of intestinal to hepatic CL_int for 16 pathways investigated

Hepatic and intestinal microsome CL_int values normalized for the P450 relative abundance and corrected for enterocyte isolation method activity differences.

Substrate	CL_tot			CL_HIM/CL_HLM
Substrate		HLM	HIM	CL_HIM/CL_HLM
	μl/min/pmol P450			%
1′-Hydroxymidazolam	5.8	5.2	90
4-Hydroxymidazolam	0.38	0.8	210
3-Hydroxydiazepam	0.07	0.022	31
Nordiazepam	0.15	0.11	73
3-Hydroxyflunitrazepam	0.08	0.04	50
Desmethylflunitrazepam	0.1	0.12	120
1′-Hydroxyalprazolam	0.002	0.002	100
4-Hydroxyalprazolam	0.05	0.01	20
1′-Hydroxytriazolam	0.19	0.05	26
4-Hydroxytriazolam	0.14	0.06	43
Quinidine	0.06	0.05	83
Testosterone	0.44	0.60	136
Nifedipine	0.49	0.30	61
Mephenytoin	0.1	0.05	50
Tolbutamide	0.06	0.02	33
Bufuralol	3.2	2.8	88