TABLE 1

The potency and efficacy of epibatidine at α4β2, α4β4, and α7 nAChRs stably expressed in mammalian cells are significantly increased by 2087101

Fluo-3-AM-loaded cells stably expressing human α3β4, α4β2, α4β4, and α7 nAChRs were challenged with epibatidine in the presence or absence of 1 μM 2087101 (α4β2, α4β4) or 3 μM 2087101 (α3β4, α7) as indicated. Cell population Ca²⁺ measurements were recorded using a FLIPR. Each value represents the mean ± S.E.M. from at least four independent experiments.