TABLE 3

Kinetic parameters (h^–1) associated with the disposition of terfenadine and preformed fexofenadine in control and DEX-treated SC rat hepatocytes Terfenadine (5 μM) or preformed fexofenadine (5 μM) were incubated with day 4 SC rat hepatocytes as described under Materials and Methods. Parameter estimates were generated by nonlinear regression of the pooled data based on the equations described in Appendix II according to the model schemes shown in Fig. 2. Bold type represents fixed parameter estimates used in simulation experiment (Fig. 5).

	Parameter	Control			Treated
	Parameter		Estimate	CV	Estimate	CV
			%		%
Model 1 (TER)	k _{TER_M→TER_C}	2.5	7	6.4	10
	k _{TER_C→TER_M}	3.2	12	8.8	8
	k _{TER_C→TER_B}	0.039	48	0.048	37
	k _{TER_C→FEX_T}	0.67	7	1.2	7
	k _{TER_C→AZA_T}	0.041	95	0.76	10
	k _{TER_C→Other}	0.86	8	0.86	8
Model 3 (preformed FEX)	k _{FEX_M→FEX_C}	0.080	3	0.065	6
	k _{FEX_C→FEX_M}	1.9	5	2.5	11
	k _{FEX_C→FEX_B}	0.44	7	0.45	16
Model 2 (generated FEX)	k _{FEX_M→FEX_C}	0.089	61	0.069	98
	k _{FEX_C→FEX_M}	1.5	17	2.0	18
	k _{FEX_C→FEX_B}	0.44	>100	0.45	>100

M, medium; C, cell; B, bile canaliculi; T, total (M + C + B)