TABLE 2

Disposition of terfenadine in control and DEX-treated (100 μM; 48 h) day 4 SC rat hepatocytes The amount (nanomoles) of terfenadine and the metabolites fexofenadine and azacyclonol in medium and hepatocytes (cells + BC) after incubation of terfenadine (5 μM) is shown. Data represent mean \m=+-\ S.D. of three individual experiments.

	Time	TER			FEX			AZA		Total	Recovery
	Time		Medium	Cells + BC	Medium	Cells + BC	Medium	Cells + BC		Total	Recovery
	h	nmol										nmol	%
Control	1	5.6 ± 1.6	3.7 ± 0.3	1.0 ± 0.4	1.5 ± 0.5	0.16 ± 0.08	0.15 ± 0.05	12 ± 3	81 ± 18
	2	3.6 ± 0.7^*	2.1 ± 0.9	2.8 ± 0.7^*	1.6 ± 0.2	0.21 ± 0.09	0.15 ± 0.02	10 ± 0.9	64 ± 6
	4	0.5 ± 0.1^*	1.6 ± 0.6	5.6 ± 0.8^*	1.3 ± 0.2	0.22 ± 0.07	0.11 ± 0.03	10 ± 0.1	67 ± 7
DEX-treated	1	3.1 ± 0.4^†	2.1 ± 0.3^†	1.8 ± 0.4	1.3 ± 0.3	1.1 ± 0.04^†	1.3 ± 0.3^†	10 ± 2	73 ± 15
	2	1.1 ± 0.0^*^†	1.1 ± 0.2	4.5 ± 0.7^†	0.8 ± 0.1^†	1.6 ± 0.2^†	2.2 ± 0.7^†	11 ± 2	74 ± 13
	4	<LLOQ	0.3 ± 0.1	6.5 ± 0.7^†	0.6 ± 0.1^*^†	2.3 ± 0.3^*^†	1.3 ± 0.0^†	11 ± 2	74 ± 12

<LLOQ, below the lower limit of quantitation
↵* P < 0.05 vs. 1 h (same treatment)
↵† P < 0.05 vs. control (same time point)