TABLE 1

Comparison of BEI and ClB in vitro values of terfenadine, generated fexofenadine, and preformed fexofenadine between control and DEX-treated (100 μM, 48 h) day 4 SC rat hepatocytes Data represent mean ± S.E.M. of three individual experiments performed in triplicate.

BEIa
ClB in vitrob
 Control
DEX-Treated
Control
DEX-Treated
% ml / min / kg
TER 15 ± 4* 9 ± 5 29 ± 10 20 ± 7
Generated FEX 15 ± 2 12 ± 4
Preformed FEX
19 ± 2
20 ± 5
5.9 ± 2.0
4.0 ± 0.9

  • ↵ a BEI values (1 h) were calculated as described under Materials and Methods

  • ↵ b ClB in vitro values (1 h) were calculated according to equations in the Appendix I

  • ↵* P < 0.05 vs. treated