IC50 values for various lipid analogs on [3H]LPA binding to particulate preparations of HeLa HF1pGPR92 cells
Analog | IC50a |
|---|---|
| μM | |
| LPA 14:0 | 0.103 ± 0.044 |
| LPA 16:0 | 0.075 ± 0.011 |
| LPA 18:0 | 0.113 ± 0.048 |
| LPA 18:1 | 0.059 ± 0.002 |
| LPE 18:1 | ≫1 |
| LPS 18:1 | ≫1 |
| LPG 18:1 | ≫1 |
| LPC 18:1 | ≫1 |
| LPC 20:0 | ≫1 |
| DGPP | ≫1 |
↵ a The values were calculated by the nonlinear regression program Prism with data obtained from competition binding experiments using approximately 2 nM [3H]LPA 18:1 as described under Materials and Methods. The results are presented as the means ± S.E.M. of three experiments