The apparent permeability Papp (centimeter per second) of E217G and EN from basolateral to apical (PappB→A) and from apical to basolateral (PappA→B) in mock-, OATP1B1-, and OATP1B1/MRP2/MDCK, respectively
PappB→A | PappA→B | PappB→A/ PappA→B | ||
|---|---|---|---|---|
| cm/s | ||||
| E217G | ||||
| Mock/MDCK | 1.48 × 10–7 ± 0.358 × 10–7 | 4.03 × 10–7 ± 2.20 × 10–7 | 0.423 ± 0.184 | |
| OATP1B1/MDCK | 3.42 × 10–6 ± 0.667 × 10–6 | 1.79 × 10–6 ± 0.452 × 10–6 | 1.93 ± 0.145* | |
| OATP1B1/MRP2/MDCK | 1.35 × 10–5 ± 0.134 × 10–5 | 3.06 × 10–7 ± 1.17 × 10–7 | 38.8 ± 10.8** | |
| EN | ||||
| Mock/MDCK | 2.77 × 10–7 ± 1.57 × 10–7 | 4.33 × 10–7 ± 0.919 × 10–7 | 0.627 ± 0.334 | |
| OATP1B1/MDCK | 5.71 × 10–7 ± 0.746 × 10–7 | 1.83 × 10–6 ± 0.770 × 10–6 | 0.374 ± 0.194 | |
| OATP1B1/MRP2/MDCK | 1.56 × 10–6 ± 0.255 × 10–6 | 4.56 × 10–7 ± 1.46 × 10–7 | 3.59 ± 0.871** | |