TABLE 1

Inhibitory activity of SC-409 on various targets


Targets

IC50
μM
Abl >10
Akt1 >10
Aur2 >10
CDC7 >10
CDK2 >200
CHK1 >10
CK1δ 0.02
CK2α >10
EGFR1 >10
ERK2 >100
FGFR1 >10
GSK3β >10
IGFR1 >10
IKK1 >100
IKK2 >100
IKKi >100
IR >10
JNK1 >200
JNK2 19.70
JNK3 69.70
Kit >10
Lck >30
Lyn >10
MAPKAP-K2 >200
Met >10
MNK >100
MSK >200
Nim >10
p38α 0.04
p38β 2.30
p38δ >100
p38γ >100
PAK4 >10
PDGFR >10
PDK1 >10
PKA 10.5
PKCβ >10
PKCzeta >30
PLK1 >10
PRAK >100
Ret >10
RSK2 >100
RSKb >200
STLK2 >10
SULU >10
TBK1 >100
TRKA >10
VEGFR2 >10
VEGFR3 >10
ZAP70
>10