TABLE 4

Gene expression in Mrp2–/– mouse liver, kidney, and intestine

Data are expressed as means ± S.E. -fold change in Mrp2–/– mice compared with wild-type mice determined from three independent experiments.

Gene
Accession No.
Liver
Kidney
Intestine
Males
Females
Males
Females
Males
Females
Abca1 NM_013454 0.8 ± 0.1 0.7 ± 0.1 0.7 ± 0.1 0.6 ± 0.2 0.9 ± 0.1 1.0 ± 0.2
Abca13 NM_178259 —b —b 0.7 ± 0.2 0.8 ± 0.2 —b —a
Abca2 NM_007379 0.7 ± 0.1 0.7 ± 0.1 0.7 ± 0.03 0.6 ± 0.2 0.6 ± 0.02 1.2 ± 0.2
Abca3 NM_013855 0.6 ± 0.1 0.8 ± 0.1 0.7 ± 0.1 0.7 ± 0.2 0.7 ± 0.1 0.9 ± 0.1
Abca4 NM_007378 —a —a 1.0 ± 0.2 0.8 ± 0.2 —b —a
Abca5 NM_147219 0.7 ± 0.1 0.6 ± 0.1 0.6 ± 0.2 0.7 ± 0.3 —a —a
Abca6 NM_147218 0.7 ± 0.1 0.8 ± 0.1 —a —a —a —a
Abca7 NM_013850 0.5 ± 0.1 0.6 ± 0.1 0.9 ± 0.2 0.5 ± 0.2 0.8 ± 0.1 0.9 ± 0.04
Abca8a NM_153145 0.7 ± 0.05 1.5 ± 0.1 0.7 ± 0.1 1.0 ± 0.2 —a 0.9 ± 0.2
Abca8b NM_013851 0.8 ± 0.1 0.7 ± 0.1 —a —a —a —a
Abca9 NM_147220 —a —a —a —a —a 1.0 ± 0.3
Abcb10 NM_019552 0.7 ± 0.1 0.7 ± 0.1 0.8 ± 0.1 0.6 ± 0.2 0.8 ± 0.1 0.8 ± 0.1
Abcb11 NM_021022 0.6 ± 0.1 0.6 ± 0.2 —b —b —a —a
Abcb1a NM_011076 0.6 ± 0.1 0.7 ± 0.1 0.7 ± 0.2 0.7 ± 0.3 1.2 ± 0.2 1.3 ± 0.2
Abcb1b NM_011075 1.0 ± 0.3 0.9 ± 0.4 0.5 ± 0.1 0.7 ± 0.2 —a —a
Abcb4 NM_008830 0.5 ± 0.1 0.8 ± 0.1 —a —a —a —a
Abcb6 NM_023732 0.8 ± 0.1 0.8 ± 0.1 0.7 ± 0.1 0.6 ± 0.2 0.8 ± 0.1 1.0 ± 0.1
Abcb9 NM_019875 —a —a 0.9c ± 0.1 0.6 ± 0.2 0.8 ± 0.1 0.8 ± 0.1
Abcc1 NM_008576 —a —a 1.0 ± 0.3 0.7 ± 0.2 —a 0.8 ± 0.1
Abcc10 NM_170680 —a —a 1.5 ± 0.5 0.6 ± 0.2 1.0 ± 0.2 0.7 ± 0.1
Abcc2 NM_013806 0.001 ± 0.0001* 0.004 ± 0.001* 0.003 ± 0.001* 0.004 ± 0.001* 0.03 ± 0.001* 0.03 ± 0.004*
Abcc3 NM_029600 0.9 ± 0.1 1.0 ± 0.1 0.6 ± 0.2 0.6d ± 0.2 1.0 ± 0.3 1.0 ± 0.1
Abcc4 GI:39771467 6.4 ± 0.9* 7.0 ± 1.7* 2.5 ± 0.2* 2.3 ± 0.3* 0.9 ± 0.2 1.3 ± 0.1*
Abcc5 NM_013790 —a —a 0.7 ± 0.1 0.7 ± 0.2 —a —a
Abcc6 NM_018795 0.7 ± 0.1 0.7 ± 0.1 0.6 ± 0.2 0.5 ± 0.2 —a —a
Abcc8 NM_011510 —b —b —a —a —a —a
Abcc9 NM_011511 0.6 ± 0.1 0.7 ± 0.1 0.7 ± 0.1 0.6 ± 0.2 0.6 ± 0.2 0.9 ± 0.3
Abcg1 NM_009593 0.9 ± 0.1 0.8 ± 0.03 0.8 ± 0.2 0.5 ± 0.2 0.6 ± 0.2 0.6 ± 0.1
Abcg2 NM_011920 0.8 ± 0.1 0.9 ± 0.1 0.7 ± 0.1 0.8 ± 0.2 0.7 ± 0.1 0.9 ± 0.1
Abcg3 NM_030239 —a —a —a —a —a —a
Abcg4 NM_138955 —b —b —b —a —a —a
Abcg5 NM_031884 0.8 ± 0.1 1.1 ± 0.1 —a —b 1.1 ± 0.1 1.2 ± 0.1
Abcg8 NM_026180 0.8 ± 0.1 0.9 ± 0.1 —a —b 1.0 ± 0.1 1.0 ± 0.1
Cftr NM_021050 —a —a —a —a 0.9 ± 0.1 0.8 ± 0.1
Slc10a1 NM_011387 0.7 ± 0.1 0.9 ± 0.2 —a —a —a —a
Slc10a3 NM_145406 0.7 ± 0.1 0.7 ± 0.1 0.6 ± 0.1 0.6 ± 0.2 0.7 ± 0.1 0.8 ± 0.2
Slc15a2 NM_021301 —a —a 0.9 ± 0.1 0.6 ± 0.2 —a —a
Slc22a1 NM_009202 0.7 ± 0.1 0.8 ± 0.1 0.8 ± 0.04 0.7 ± 0.2 0.6 ± 0.3 0.6 ± 0.3
Slc22a12 NM_009203 —a —b 0.9 ± 0.2 0.9 ± 0.3 —b —b
Slc22a13 NM_133980 —b —b 0.7 ± 0.1 0.8 ± 0.2 —b —b
Slc22a17 NM_021551 —a —a 0.7 ± 0.1 0.8 ± 0.2 —a —a
Slc22a18 NM_008767 0.7 ± 0.1 0.9 ± 0.1 0.7 ± 0.2 0.7 ± 0.2 0.9 ± 0.1 0.9 ± 0.1
Slc22a2 NM_013667 —b —b 0.7 ± 0.1 0.7 ± 0.2 —b —b
Slc22a3 NM_011395 0.6 ± 0.1 0.6 ± 0.1 —a —a —a —a
Slc22a4 NM_019687 1.1 ± 0.2 0.8 ± 0.3 0.6 ± 0.2 0.8 ± 0.2 1.1 ± 0.2 0.9 ± 0.04
Slc22a5 NM_011396 0.6 ± 0.3 1.4 ± 0.6 0.7 ± 0.1 0.6 ± 0.2 0.8 ± 0.1 0.6 ± 0.2
Slc22a6 NM_008766 —b —b 0.8 ± 0.3 0.7 ± 0.2 —b —b
Slc22a7 NM_144856 1.3 ± 0.2 0.4 ± 0.02* 0.7 ± 0.1 0.7 ± 0.2 —b —b
Slc22a8 NM_031194 —b —b 0.7 ± 0.1 0.7 ± 0.2 —a —b
Slc22a9 NM_019723 —a —a —a —a 0.8 ± 0.1 1.1 ± 0.2
Slco1a1 NM_013797 0.6 ± 0.1 0.6 ± 0.1 0.8c ± 0.3 —b —a,b —b
Slco1a4 NM_030687 1.2 ± 0.1 1.2 ± 0.2 —a —a —a —b
Slco1a5 NM_130861 —b —b —b —b —b —b
Slco1a6 NM_023718 —b —b 0.9c ± 0.2 0.8 ± 0.3 —b —b
Slco1b2 NM_020495 0.7 ± 0.1 0.9 ± 0.2 —b —b —b —b
Slco1c1 NM_021471 —a —a —a —a —b —b
Slco2a1 NM_033314 0.7 ± 0.1 0.8 ± 0.1 0.8 ± 0.1 0.9 ± 0.2 0.8 ± 0.2 0.8 ± 0.2
Slco3a1 NM_023908 —a —a 0.7 ± 0.2 0.9 ± 0.2 1.4 ± 0.4 0.9 ± 0.02
Slco4a1 NM_148933 —b —b —a —b —b —b
Tap1 NM_013683 0.5 ± 0.1 0.7 ± 0.1 0.6 ± 0.1 0.5 ± 0.2 0.7 ± 0.1 0.8 ± 0.1
Tap2 NM_011530 0.5 ± 0.04 0.5 ± 0.2 0.6 ± 0.1 0.7 ± 0.3 0.7 ± 0.1 1.1 ± 0.2
Acat2 NM_009338 0.6e 0.7e 0.9 ± 0.2 0.9 ± 0.2 1.0 ± 0.1 1.4 ± 0.2
Cyp1a1 Y00071,K02588 —a —a —a —a —a —a
Cyp1a1 NM_009992 —b —b —a —b —b —a
Cyp1a2 NM_009993 0.9 ± 0.1 1.1 ± 0.2 —a —b —a —b
Cyp1b1 NM_009994 —a —a 0.5 ± 0.1 0.6 ± 0.2 0.8 ± 0.1 —a
Cyp27a1 NM_024264 0.8 ± 0.1 1.1 ± 0.1 0.9 ± 0.1 0.7 ± 0.3 1.1 ± 0.2 0.9 ± 0.1
Cyp2b10 NM_009998 —a —a —a —b —a —a
Cyp2b13 NM_007813 —a 0.1d ± 0.02* —b —b —b —b
Cyp2b19 NM_007814 —a —a —a —a —a —b
Cyp2b9 NM_010000 —a 0.5d ± 0.02* —b —b —b —b
Cyp2d9 NM_010006 0.7c ± 0.2 0.6 ± 0.1 0.3c ± 0.1 0.5 ± 0.2 —a —a
Cyp2e1 NM_021282 0.7 ± 0.2 0.6 ± 0.2 0.7 ± 0.1 0.7 ± 0.2 —b 1.1 ± 0.05
Cyp39a1 NM_018887 0.9 ± 0.1 0.9 ± 0.1 —a —a —a —a
Cyp3a11 NM_007818 1.1 ± 0.1 1.3 ± 0.3 —a —a 1.2 ± 0.04 1.3 ± 0.3
Cyp3a13 NM_007819 1.7 ± 0.2 1.1 ± 0.2 —a —a 1.2 ± 0.2 1.0 ± 0.02
Cyp3a16 NM_007820 —a 1.0d ± 0.2 —b —b —a —b
Cyp3a41 NM_017396 —a 1.2d ± 0.2 —b —b —b —b
Cyp4a12 NM_172306 0.7c ± 0.1 —a 0.6c ± 0.1 0.6 ± 0.1 —b —b
Cyp4a14 NM_007822 0.4 ± 0.1* 0.8 ± 0.1 0.5 ± 0.1* 0.8 ± 0.2 —a —a
Cyp51 NM_020010 0.7 ± 0.1 0.8 ± 0.1 0.9 ± 0.2 0.7 ± 0.2 0.7 ± 0.1 0.7 ± 0.1
Cyp7a1 NM_007824 2.2 ± 0.2* 1.5 ± 0.1 —b —b —a —b
Fasn NM_007988 0.4e 0.5e 1.2 ± 0.3 0.7 ± 0.2 0.9 ± 0.1 0.9 ± 0.1
Gclc NM_010295 0.5 ± 0.1 1.6 ± 0.3 0.7 ± 0.1 0.8 ± 0.2 1.65 ± 0.2 1.0 ± 0.1
Gss NM_008180 0.9 ± 0.1 1.1 ± 0.1 0.9 ± 0.2 0.8 ± 0.3 0.8 ± 0.1 1.1 ± 0.04
Gsta2 NM_008182 —b —b —b —b —b —b
Gstp1 NM_181796 0.8 ± 0.1 —a 0.9 ± 0.2 0.8 ± 0.2 1.1 ± 0.1 0.9 ± 0.03
Mvk NM_023556 0.5e 0.6e 0.9 ± 0.02 0.6 ± 0.1 0.8 ± 0.1 0.7 ± 0.1
Nr1i2 NM_010936 1.2 ± 0.1 1.1 ± 0.1 1.2 ± 0.3 1.2 ± 0.1 1.5 ± 0.3 1.6 ± 0.5
Nr1i3 NM_009803 1.0 ± 0.2 1.5 ± 0.04 0.7 ± 0.1 1.5 ± 0.1 1.1 ± 0.2 1.4 ± 0.1
Nr1h3 NM_013839 1.0 ± 0.1 1.0 ± 0.1 1.1 ± 0.2 1.0 ± 0.1 1.1 ± 0.1 1.1 ± 0.2
Nr1h4 NM_009108 1.1 ± 0.1 1.3 ± 0.1 1.2 ± 0.2 1.6 ± 0.1 0.9 ± 0.1 1.4 ± 0.2
Pmvk NM_026784 0.6e 0.7e 0.6 ± 0.2 0.8 ± 0.2 0.7 ± 0.1 0.8 ± 0.1
Sult1a1 NM_133670 0.8 ± 0.1 0.9 ± 0.1 0.9 ± 0.1 0.8 ± 0.2 1.1 ± 0.2 0.8 ± 0.1
Sult1d1 NM_016771 1.2 ± 0.2 0.9 ± 0.2 1.0 ± 0.1 0.8 ± 0.2 1.3 ± 0.1 1.1 ± 0.1
Ugt1a1 NM_013701 1.1 ± 0.2 1.2 ± 0.1 1.9 ± 0.3 1.0d ± 0.3 —b —b
Ugt2a1 NM_053184 —b —a —b —b —b —b
Ugt8
NM_011674
—a
—a
0.8c ± 0.1
0.6 ± 0.1
—a
—b

  • ↵* P < 0.05, ΔCt value significantly different from wild-type mice.

  • ↵ a Low gene expression Ct value >32).

  • ↵ b The gene was not amplified.

  • ↵ c Gene expression in male was higher than in female mice.

  • ↵ d Gene expression in female was higher than in male mice.

  • ↵ e Data were expressed as average value of duplicated experiments.