Stimulation of [35S]GTPγS binding in C6μ cells
Values were determined using a concentration of 0.1 nM [35S]GTPγS as described under Materials and Methods. Values represent the mean ± S.E.M. of three experiments each performed in duplicate.
| Drug | % DAMGO Maximum | EC50 |
|---|---|---|
| nM | ||
| Methadone | 100 ± 7.0 | 123.0 ± 9.1 |
| Oxymorphone | 86.6 ± 2.4 | 34.0 ± 8.2 |
| Morphine | 83.8 ± 1.0 | 78.4 ± 19.0 |
| Heroin | 83.4 ± 6.4 | 2735 ± 57.0 |
| Fentanyl | 77.1 ± 6.0 | 128 ± 25.3 |
| Codeine | 67.1 ± 5.9 | 21,015 ± 6090 |
| Oxycodone | 66.1 ± 3.6 | 373 ± 125 |
| Hydromorphone | 65.1 ± 2.2 | 17.6 ± 3.6 |
| Hydrocodone | 59.5 ± 4.1 | 1037 ± 216 |