TABLE 4

Percentage of the dose recovereda as ATV or OH ATV from rat livers perfused with ATV alone and livers coperfused with RIF

Matrix
Perfusate
Liver
Bile
Treatment ATV OH ATVb ATV OH ATVb ATV OH ATVb Total
Control 7.58 ± 3.08 11.4 ± 1.7 35.7 ± 5.6 15.4 ± 5.8 7.41 ± 2.00 1.90 ± 0.49 79.3 ± 8.4
RIF 5 μM 13.2 ± 1.6* 17.1 ± 2.5** 24.5 ± 4.1* 7.52 ± 3.31* 5.92 ± 1.23 1.80 ± 0.94 70.0 ± 6.5
RIF 10 μM 19.4 ± 4.5*** 22.6 ± 3.3*** 26.7 ± 4.7 7.21 ± 1.91* 2.60 ± 0.90*** 0.94 ± 0.59** 79.4 ± 8.2
RIF 50 μM
20.7 ± 2.5***
23.1 ± 1.6***
41.2 ± 10.7
6.75 ± 0.97**
0.96 ± 0.29***
0.41 ± 0.12***
93.1 ± 13.9

  • *, P < 0.05; **, P < 0.01; ***, P < 0.001 significantly different from control.

  • ↵ a Mean ± S.D., n = 5/group.

  • ↵ b OH ATV is the sum of 2-OH ATV and 4-OH ATV.