TABLE 3

Comparison of parameters between control rat livers perfused with ATV alone and livers coperfused with RIF

Parametera
Treatment Group
Control
RIF 5 μM
RIF 10 μM
RIF 50 μM
ATV AUCb (μM · min) 8.55 ± 1.89 13.3 ± 1.7* 17.8 ± 3.1*** 21.4 ± 3.0***
2-OH ATV AUCb (μM · min) 2.93 ± 0.48 3.51 ± 0.75 5.33 ± 0.64** 5.84 ± 0.71***
4-OH ATV AUCb (μM · min) 2.44 ± 0.36 2.90 ± 0.92 4.44 ± 0.06** 5.23 ± 0.08***
OH ATV AUC/ATV AUC 0.66 ± 0.18 0.48 ± 0.08 0.56 ± 0.09 0.53 ± 0.08
OH ATV/ATV in liverc 0.43 ± 0.16 0.35 ± 0.15 0.28 ± 0.11 0.17 ± 0.05*
CLb (ml/min)d 1.31 ± 0.50 0.64 ± 0.18** 0.21 ± 0.06*** 0.064 ± 0.019***
Bile/liver (ATV)e 0.21 ± 0.04 0.26 ± 0.10 0.10 ± 0.05 0.026 ± 0.019***
Bile/liver (OH ATV)f 0.14 ± 0.06 0.27 ± 0.15 0.42 ± 0.31 0.059 ± 0.017
RIF in liverg
N/A
11.2 ± 2.1
18.4 ± 3.6
121 ± 19

  • *, P < 0.05; **, P < 0.01; ***, P < 0.001 significantly different from control.

  • ↵ a Mean ± S.D., n = 5/group.

  • ↵ b AUC calculated using the linear trapezoidal method up to 1 h.

  • ↵ c Ratio of amount of total OH ATV formed to amount of ATV retained in liver at 1 h.

  • ↵ d Biliary clearance (quotient of the cumulative amount of ATV excreted into bile and the ATV AUC).

  • ↵ e Ratio of amount of ATV in bile to that in liver at 1 h.

  • ↵ f Ratio of amount of total OH ATV in bile to that in liver at 1 h.

  • ↵ g Concentration of RIF detected in liver at 1 h.