TABLE 1

ATV (5 μM) transport and inhibition across MII and MII-cMOAT cell monolayers




Condition

Papp (B → A) × 10−6a

Net flux ratio (B → A/ A → B)a

Intracellular ATV (B → C)a,b
cm s −1 pmol
MII Control 1.52 ± 0.23 1.94 ± 0.43 70.7 ± 15.5
With RIF (50 μM) 1.22 ± 0.09* 1.10 ± 0.24 87.0 ± 11.7
MII-cMOAT Control 2.65 ± 0.23 3.03 ± 0.43 81.7 ± 16.6

With RIF (50 μM)
1.26 ± 0.09**
0.95 ± 0.24**
118.5 ± 9.4*
  • *, P < 0.05; **, P < 0.01, RIF-treated groups significantly different from ATV only controls.

  • a Each value represents mean ± S.D., n = 4.

  • b Intracellular accumulation of ATV at 3 h after basolateral doses of ATV to the donor side.