TABLE 1
In vitro inhibition of rat, rabbit, and human lung ACE and renal NEP by GW796406 and omapatrilat
Species
GW796406
Omapatrilat
ACE IC
50
NEP IC
50
ACE/NEP Ratio
ACE IC
50
NEP IC
50
ACE/NEP Ratio
nM
nM
Rat
2.9
1.1
2.6
2.1
8.2
0.3
Rabbit
3.9
2.5
1.6
2.0
3.2
0.6
Human
4.7
1.6
2.9
1.7
5.3
0.3