TABLE 1

Lack of difference in uptake of digoxin by periportal and perivenous isolated rat hepatocytes in which the kinetics were best described by saturable and nonsaturable components (fitted with a weighting scheme of 1/observation2)




Km a

Vmax a

PSuptakeb

CLuptakec
nM pmol / min / mg μl / min / mg
Periportal hepatocytes (n = 4) 180 ± 112 13 ± 8 9.2 ± 1.3 83 ± 29
Perivenous hepatocytes (n = 4)
390 ± 406
18 ± 4.9
10.7 ± 2.5
111 ± 80
  • a Saturable component

  • b Nonsaturable or linear uptake clearance

  • c Total hepatocyte uptake clearance (Vmax/Km + PSuptake)