Lack of difference in uptake of digoxin by periportal and perivenous isolated rat hepatocytes in which the kinetics were best described by saturable and nonsaturable components (fitted with a weighting scheme of 1/observation2)
Km a | Vmax a | PSuptakeb | CLuptakec | ||
|---|---|---|---|---|---|
| nM | pmol / min / mg | μl / min / mg | |||
| Periportal hepatocytes (n = 4) | 180 ± 112 | 13 ± 8 | 9.2 ± 1.3 | 83 ± 29 | |
| Perivenous hepatocytes (n = 4) | 390 ± 406 | 18 ± 4.9 | 10.7 ± 2.5 | 111 ± 80 | |