TABLE 4

Assigned and fitted parameters to zonal model shown in Fig. 4 based on the fit to the average data

KHB-Perfused Livers
Rbc-Alb-Perfused Livers (20% rbc-1% Albumin)
Forced Fitting
Q (ml/min/g) 3.58 0.811
Hct 0 0.142
VR (ml/g) 14.6a 12.2
VS (ml/g) 0.149b 0.149
VL (ml/g) 0.663c 0.663
k′rp (min–1) 0 1.81
kpr (min–1) 0 0.468
f p 1 0.64
CLin (ml/min/g) 12.1d 12.1 12.1
CLef (ml/min/g) 8.52 ± 54.0e 14.3 ± 388 11.4 ± 776
(9.28 ± 177)f (14.1 ± 204) (16.0 ± 262)
CLint,met (ml/min/g) 0.143 ± 0.901 0.202 ± 5.49 0.127 ± 8.66
(0.153 ± 2.91) (0.197 ± 2.84) (0.226 ± 3.70)
CLint,sec (ml/min/g) 0.054 ± 0.345 0.017 ± 0.469 0.025 ± 1.68
(0.059 ± 1.13) (0.017 ± 0.250) (0.046 ± 0.744)
f t 0.018 ± 0.116 0.051 ± 1.40 0.034 ± 2.33
(0.017 ± 0.321)
(0.052 ± 0.749)
(0.019 ± 0.311)

  • ↵ a Mean of reservoir volume normalized to averaged liver weight

  • ↵ b Sinusoidal blood volume of liver, taken from Pang et al. (1988)

  • ↵ c Cellular water space of liver, taken from Pang et al. (1988)

  • ↵ d Calculated from data of Table 1; the data were scaled-up with the scaling factor (α/β, where α is 1.25 × 108 cells/g liver and β is 1 × 106 cells/mg protein)

  • ↵ e Fitted parameters when the metabolic activity, CLint,met, was distributed heterogeneously (10:30:60% of total intrinsic clearance at zones 1, 2, and 3, respectively)

  • ↵ f Fitted parameters when CLint,met was distributed homogeneously in zones 1, 2, and 3