Isoform | Cimetidine | Famotidine | Ranitidine | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Km | Vmax | Vmax/Km | Km | Vmax | Vmax/Km | Km | Vmax | Vmax/Km | |||||||
μM | pmol / min / mg protein | μl / min / mg protein | μM | pmol / min / mg protein | μl / min / mg protein | μM | pmol / min / mg protein | μl / min / mg protein | |||||||
hOAT2 | N.D. | N.D. | 1.65 (1) | N.T. | 396 ± 41 | 4320 ± 358 | 10.9 (6.61) | ||||||||
hOAT3 | 149 ± 35 | 1470 ± 230 | 9.86 (1) | 124 ± 4 | 448 ± 10 | 3.61 (0.37) | 234 ± 49 | 551 ± 49 | 2.35 (0.24) | ||||||
rOat3 | 90.7 ± 4.8 | 512 ± 17 | 5.64 (1) | 345 ± 22 | 252 ± 12 | 0.73 (0.13) | 155 ± 9 | 1660 ± 63 | 10.7 (1.90) |
N.D., not determined; N.T., not transported.