TABLE 1

Apparent rates of occupancy and their 95% confidence intervals from in vivo binding studies Numbers in parentheses represent 95% CL.


Drug

Time Points over which Data Were Linear

Apparent Occupancy Rate

Initial Two Time Points

Apparent Occupancy Rate
% occupancy/min % occupancy/min
Cocaine 5–30 min 2.04 (1.64–2.45) 5 and 10 min 3.03 (0.451–5.60)
GBR 12909 5–60 min 1.24 (0.952–1.53) 5 and 30 min 1.72 (0.892–2.55)
AHN 1-055 10–150 min 0.363 (0.272–0.455) 10 and 30 min 1.05 (0.216–1.88)
AHN 2-005
10–210 min
0.330 (0.239–0.420)
10 and 30 min
0.840 (0.0146–1.70)