TABLE 2

Renal pharmacokinetics of GlySar plasma concentrations in PEPT2+/+ and PEPT2-/- mice


Parameter

PEPT2+/+

PEPT2–/–
CLR (ml/min) 0.11 (0.03)a 0.24 (0.03)b
GFR (ml/min) 0.23 (0.08) 0.27 (0.03)
fu 0.93 (0.02) 0.94 (0.02)
fe60 0.56 (0.06) 0.66 (0.02)
ER 0.54 (0.05) 0.94 (0.10)b
F 0.46 (0.05) 0.06 (0.10)b
F 1 0.06 0.06 (0.10)
F 2 0.43 (0.05) 0
%PEPT1 14 (2) 100
%PEPT2
86 (2)
0
  • CLR, renal clearance of GlySar; GFR, glomerular filtration rate (of inulin); fu, unbound fraction of GlySar in plasma; fe60, fraction of GlySar excreted unchanged in the urine over 60 min (Ae60/Doseiv); ER, excretion ratio of GlySar; F, fraction of available GlySar reabsorbed; F1, fraction of available GlySar reabsorbed by PEPT1; F2, fraction of available GlySar reabsorbed by PEPT2; %PEPT1, percentage of reabsorbed GlySar that occurs via PEPT1; %PEPT2, percentage of reabsorbed GlySar that occurs via PEPT2.

  • a Data represented as mean ± S.E. (n = 4)

  • b P < 0.05 compared with PEPT2+/+ (wild-type) mice