Pharmacokinetic parameters of [14C]HA after i.v. administration to normal and 5/6 Nx rats 4 weeks after nephrectomy (0.1 mg/kg) GFR was assumed to be equal to the renal clearance of inulin in normal or 5/6 Nx rats. Excretion ratio was calculated by dividing the renal clearance by the unbound fraction and GFR. Each value represents the mean ± S.E. of four or five experiments.
Parameter | Normal Rats | 5/6 Nx Rats |
|---|---|---|
| AUC (% of dose/ml · min) | 25.1 ± 1.1 | 165 ± 49* |
| t1/2β (min) | 21.9 ± 1.3 | 156 ± 64* |
| Vd,ss (ml/kg) | 440 ± 22 | 401 ± 65 |
| CLtot (ml/min/kg) | 19.3 ± 0.7 | 3.55 ± 1.57** |
| CLrenal (mL/min/kg) | 18.1 ± 0.7 | 2.68 ± 1.19** |
| CLbiliary (ml/min/kg) | 0.092 ± 0.010 | 0.10 ± 0.01 |
| GFR (ml/min/kg) | 2.43 ± 0.18 | 0.59 ± 0.13** |
| fu (%) | 47.4 ± 1.7 | 60.3 ± 0.8** |
| Excretion ratio | 15.7 | 7.56 |