ED50 values (with 95% confidence limits) for antinociception, hypothermia, and catalepsy following i.v. administration of Δ9-THC or marijuana extract, inhaled marijuana smoke, inhaled Δ9-THC, or marijuana extract on placebo paper (method 1) or inhaled Δ9-THC on placebo or LGM material (method 2) Potency ratios (with 95% confidence limits) are listed for each comparison. No significant potency differences between treatments (at each administration route) were observed. Intravenous ED50 values are expressed as milligrams per kilogram. Inhalation ED50 values are expressed as milligrams of Δ9-THC in the matrix prior to burning (shared between six mice).
Antinociception | Hypothermia | Catalepsy | |
|---|---|---|---|
| Intravenous | |||
| Δ9-THC | 0.7 (0.3-1.7) | 2.0 (1.1-1.8) | 1.2 (0.2-6.3) |
| Extract | 0.3 (0.1-0.5) | 2.4 (1.4-4.1) | 1.6 (0.4-6.8) |
| Potency ratio | 0.4 (0.1-1.2) | 1.5 (0.8-2.9) | 0.5 (0.1-2.1) |
| Inhalation | |||
| Marijuana | 6.7 (3.6-13.5) | 2.9 (1.6-5.3) | 3.7 (1.8-7.5) |
| Inhalation: method 1 | |||
| Δ9-THC | 1.7 (0.8-3.4) | 4.4 (1.4-13.3) | 3.6 (2.2-6.1) |
| Extract | 1.9 (1.0-3.7) | 2.1 (1.6-2.7) | 4.0 (2.1-7.6) |
| Potency ratio | 1.0 (0.3-3.0) | 0.7 (0.2-2.6) | 1.0 (0.5-2.4) |
| Inhalation: method 2 | |||
| Placebo | 3.2 (1.9-5.4) | 6.5 (3.5-11.9) | 4.3 (2.7-6.9) |
| LGM | 2.3 (1.5-3.6) | 6.6 (4.0-10.7) | 2.4 (1.5-3.8) |
| Potency ratio | 0.7 (0.3-1.3) | 1.1 (0.6-2.4) | 0.6 (0.3-1.1) |