List of observed in vivo and predicted AUCi/AUC ratios for 26 drug interactions with azole inhibitors using midazolam, testosterone, quinidine, and nifedipine as probes
Interaction | Mean AUCi/AUC in Vivo | Mean AUCi/AUC Predicted | fmCYP3A4 | References | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Midazolam | Testosterone | Quinidine | Nifedipine | |||||||
| Ketoconazole | ||||||||||
| + Midazolam | 15.9 | 14.1 | 6.5 | 14.4 | 15.7 | 0.99 | Olkkola et al. (1994) | |||
| + Triazolam | 9.2 | 12.5 | 6.2 | 12.7 | 13.7 | 0.98 | Varhe et al. (1994) | |||
| + Triazolam | 13.7 | 12.5 | 6.2 | 12.7 | 13.7 | 0.98 | Greenblatt et al. (1998) | |||
| + Triazolam | 9.2 | 12.5 | 6.2 | 12.7 | 13.7 | 0.98 | von Moltke et al. (1996) | |||
| + Alprazolam | 3.98 | 4.0 | 3.2 | 4.0 | 4.1 | 0.80 | Greenblatt et al. (1998) | |||
| + Cyclosporine | 4.9 | 16.3 | 6.9 | 16.6 | 18.4 | 1.00 | Gomez et al. (1995); Foradori et al. (1998) | |||
| + Nisoldipine | 24.4 | 14.1 | 6.5 | 14.4 | 15.7 | 0.99 | Heinig et al. (1999) | |||
| + Tacrolimus | 1.2 | 10.6 | 6.5 | 14.4 | 15.7 | 0.99 | Floren et al. (1997) | |||
| Itraconazole | ||||||||||
| + Quinidine | 2.4 | 3.1 | 3.4 | 3.2 | 2.9 | 0.76 | Kaukonen et al. (1997) | |||
| + Felodipine | 6.3 | 8.0 | 12.5 | 9.3 | 6.5 | 0.99 | Jalava et al. (1997) | |||
| + Simvastatin | 18.4 | 8.0 | 12.5 | 9.3 | 6.5 | 0.99 | Neuvonen et al. (1998) | |||
| + Alprazolam | 2.7 | 3.4 | 3.9 | 3.6 | 3.2 | 0.80 | Yasui et al. (1998) | |||
| + Midazolam | 5.7 | 5.5 | 7.1 | 6.3 | 3.2 | 0.99 | Ahonen et al. (1995) | |||
| + Midazolam | 6.4 | 8.0 | 12.5 | 9.3 | 6.5 | 0.99 | Backman et al. (1998); Olkkola et al. (1996) | |||
| + Midazolam | 10.8 | 11.6 | 20.3 | 14.6 | 13.4 | 0.99 | Olkkola et al. (1994) | |||
| + Triazolam | 10.5 | 7.5 | 11.2 | 8.5 | 6.2 | 0.98 | Varhe et al. (1994) | |||
| + Atorvastatin | 3.6 | 8.0 | 12.2 | 9.3 | 6.5 | 0.99 | Kantola et al. (1998) | |||
| + Cerivastatin | 1.15 | 1.5 | 1.5 | 1.5 | 1.5 | 0.37 | Kantola et al. (1999) | |||
| + Lovastatin | 8.6 | 3.9 | 4.6 | 4.3 | 2.7 | 0.90 | Kivisto et al. (1998) | |||
| + Lovastatin | 21.6 | 5.2 | 6.1 | 5.3 | 4.3 | 0.90 | Neuvonen and Jalava (1996) | |||
| Fluconazole | ||||||||||
| + Midazolam | 3.6 | 2.8 | 1.8 | 2.6 | 1.15 | 0.99 | Olkkola et al. (1996) | |||
| + Triazolam | 1.6 | 1.5 | 1.2 | 1.4 | 1.02 | 0.98 | Varhe et al. (1996a) | |||
| + Triazolam | 2.3 | 1.9 | 1.4 | 1.8 | 1.05 | 0.98 | Varhe et al. (1996b) | |||
| + Triazolam | 4.4 | 2.7 | 1.8 | 2.6 | 1.15 | 0.98 | Varhe et al. (1996a) | |||
| + Cyclosporine | 1.8 | 2.8 | 1.8 | 2.6 | 1.15 | 1.00 | Canafax et al. (1991) | |||
| + Rifabutin | 1.8 | 2.4 | 1.7 | 2.3 | 1.13 | 0.90 | Trapnell et al. (1996) | |||