TABLE 2

Potencies of cocaine for blocking [3H]dopamine or [3H]PEA transport by the dopamine transporter in cloned human DAT expressed in HEK-293 cells or rodent DAT derived from striatal synaptosomes


Reference/Source

(—)-Cocaine vs. [3H]DA (IC50)

(—)-Cocaine vs. [3H]PEA (IC50)

DAT Source
nM
Current results 167 19.8 Human DAT in HEK cells
Yatin et al. (2002) 221 Human DAT in HEK cells
Eshleman et al. (1999) 278 Human DAT in HEK cells
Calligaro and Eldefrawi (1987) 770 Rat striatal synaptosomes
Debler et al. (1988) 200 Mouse striatal synaptosomes
Hyttel (1978) 310 Rat striatal synaptosomes
Matecka et al. (1996)
478

Rat striatal synaptosomes