Plasma pharmacokinetic parameters of 125I-Aβ40 in WT and APP,PS1 mice Data are mean ± S.D.
Parameter | 8 Weeks | 24 Weeks | p a | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | APP,PS1 | p | WT | APP,PS1 | p | ||||||
| Cmax (μCi/ml) | 18.9 ± 2.0 | 10.5 ± 2.1 | ** | 17.4 ± 2.7 | 14.7 ± 4.1 | N.S. | N.S. | ||||
| t1/2 (α) (min) | 0.8 ± 0.1 | 0.9 ± 0.4 | N.S. | 0.9 ± 0.1 | 1.1 ± 0.3 | N.S. | N.S. | ||||
| t1/2 (β) (min) | 11.9 ± 5.1 | 9.4 ± 6.1 | N.S. | 9.2 ± 2.3 | 15.0 ± 11.3 | N.S. | N.S. | ||||
| Clearance (ml/min/g) | 0.09 ± 0.02 | 0.15 ± 0.02 | * | 0.09 ± 0.02 | 0.09 ± 0.02 | N.S. | * | ||||
| VSS (ml/g) | 1.0 ± 0.3 | 1.4 ± 0.7 | N.S. | 0.9 ± 0.17 | 1.2 ± 0.76 | N.S. | N.S. | ||||
| AUC (min × μCi/ml) | 53.0 ± 11.6 | 35.0 ± 4.5 | * | 50.5 ± 7.3 | 52.1 ± 9.6 | N.S. | * | ||||
N.S., nonsignificant, p > 0.05. Statistical significance was indicated by *p < 0.05 and **p < 0.01 using Student's t test.
↵ a Comparison between 8- and 24-week-old APP,PS1 mice