TABLE 2

Effect of UGT1A6 genetic polymorphism carrier status on glucuronidation, protein, and mRNA content in livers without an alcohol exposure history

Variable
n
Serotonin Glucuronidation (nmol/min/mg)
4-Nitrophenol Glucuronidation (nmol/min/mg)
UGT1A6 Protein (Relative to Lowest)
UGT1A6 mRNA (Relative to Lowest)
Median
(25—75%)
Median
(25—75%)
Median
(25—75%)
Median
(25—75%)
-1535 g→a
   Non-carrier 21 2.6 2.0—4.9 14 9—24 28 12—41 2.2 1.7—5.2
   Carrier 13 2.9 2.4—4.7 11 9—21 22 10—43 3.6 2.7—5.0
-427 g→c
   Non-carrier 19 2.6 2.1—5.1 14 9—25 28 16—41 2.2 1.7—4.5
   Carrier 15 2.9 2.3—4.2 11 8—19 22 8—52 3.6 2.6—5.5
S7Aa
   Non-carrier 16 2.6 2.1—3.6 13 9—23 29 14—39 3.9* 2.8—6.8
   Carrier 18 3.4 2.1—6.0 12 9—21 27 8—46 2.0* 1.6—3.5
T181A
   Non-carrier 18 2.6 2.0—4.0 13 9—22 29 13—44 3.8 2.3—5.9
   Carrier 16 3.4 2.3—5.9 12 9—21 27 8—41 2.3 1.7—4.1
R184S
   Non-carrier 17 2.5 2.0—3.5 11 9—22 24 12—38 3.8 2.5—6.4
   Carrier
17
3.6
2.3—6.0
12
9—21
28
9—49
2.2
1.6—3.8

  • Differences were analyzed by Mann-Whitney rank sum test (*p < 0.05).

  • ↵ a Identical data were also obtained for promoter polymorphisms -1710 c→g, -1306 to -1310 delete (aggag), and -652 g→a, which were in complete linkage disequilibrium with S7A, and also for -1377 g→a, which was in partial linkage disequilibrium with S7A