PS values and unbound fraction of seven model compounds in rat plasma and brain tissue (mean ± S.D., n = 4)
N.A., not available
a Liu et al. (2004)
b BPko and BPwt represents the brain-to-plasma concentration ratio in mdr1a/1b gene knockout and FVB mice, respectively
c Unbound fraction in brain tissue determined using brain homogenate
d Doran et al. (2005)
e Smith et al. (2001)
f X. Liu, unpublished data