TABLE 1

PS values and unbound fraction of seven model compounds in rat plasma and brain tissue (mean ± S.D., n = 4)

TABLE 1

  • N.A., not available

  • a Liu et al. (2004)

  • b BPko and BPwt represents the brain-to-plasma concentration ratio in mdr1a/1b gene knockout and FVB mice, respectively

  • c Unbound fraction in brain tissue determined using brain homogenate

  • d Doran et al. (2005)

  • e Smith et al. (2001)

  • f X. Liu, unpublished data