TABLE 1

Overlap in alterations of gene expression induced by lovastatin, simvastatin, and pravastatin in the cerebral cortex of C57BL/6 mice

Gene Accession Number Description -Fold Change (p Values)
Lovastatin Pravastatin Simvastatin
Cell growth
   Enc1 U65079 Ectodermal-neural cortex 1 3.3 (0.011) 4.2 (0.004) 6.1 (0.001)
   Cotl1 AI837006 Coactosin-like 1 (Dictyostelium) 4.4 (0.003) 5.4 (0.001) 6.4 (0.001)
   Arhu NM_133955 Ras homolog family, member U 3.8 (0.004) 2.0 (0.048) 3.3 (0.007)
   Fin15 U42384 Fibroblast growth factor inducible 15 –2.1 (0.019) –2.2 (0.012) –2.6 (0.006)
Signaling and trafficking
   MCT2 AF058054 Monocarboxylic acid transporter-2 2.3 (0.005) 2.5 (0.02) 2.5 (0.024)
   Sdc4 D89571 Syndecan 4 3.0 (0.011) 3.2 (0.005) 2.2 (0.009)
   Hba-a1 V00714 α-globin 1.9 (0.007) 1.9 (0.003) 2.2 (0.001)
   Hbb-b2 V00722 β-1-globin 2.0 (0.02) 1.9 (0.033) 2.4 (0.003)
   LOC55933 AF015811 Putative lysophosphatidic acid acyltransferase 2.3 (0.037) 2.1 (0.05) 2.7 (0.028)
Other
   Polg U53584 Polymerase (DNA directed), γ 4.0 (0.005) 3.2 (0.025) 4.0 (0.006)
   Zik1 U69133 Zinc finger protein interacting with K protein 1 2.4 (0.004) 2.0 (0.011) 2.2 (0.011)
   Avp M88354 Vasopressin-neurophysin II 2.4 (0.001) 2.2 (0.001) 2.7 (0.016)
   Xlr3b L22977 X-linked lymphocyte-regulated 3b 2.8 (0.002) 2.0 (0.006) 3.1 (0.002)
   Vwf AI843063 Von Willebrand factor homolog 2.6 (0.02) 4.0 (0.003) 2.5 (0.023)
   Impact D87973 Imprinted and ancient 2.9 (0.03) 2.3 (0.003) 2.8 (0.023)