TABLE 2

Distinct alterations in gene expression induced by lovastatin, simvastatin, or pravastatin in the cerebral cortex of C57BL/6 mice

Gene Accession Number Description -Fold Change (p Values)
Lovastatin Pravastatin Simvastatin
Cell growth
   Igfbp3 A1842277 Insulin-like growth factor binding protein 3 2.1 (0.003) 2.4 (0.004)
   Hk1 J05277 Hexokinase 1 2.1 (0.007) 2.0 (0.02)
   Gpi1 AV295044 Glucose phosphate isomerase 1 –1.8 (0.014)
   Lgals8 AA760613 Lectin, β-galactoside binding 2.8 (0.015) 2.6 (0.023)
   c-fos V00727 Mouse c-fos oncogene –2.0 (0.015)
   c-myc L00039 c-MYC 2.2 (0.02) 2.5 (0.012)
   H1.2 J03482 Mouse histone H1 2.1 (0.005)
   Bcl-2 L31532 B-cell leukemia/lymphoma 2 3.4 (0.016)
   Col3a1 X52046 α3 subunit –2.0 (0.007)
   Acvr1 L15436 Activin A receptor, type 1 1.9 (0.007) 2.5 (0.004)
   Ccl27 AA672499 Chemokine (C-C motif) ligand 27 2.2 (0.018)
   Tm4sf8 AI843488 Transmembrane 4 superfamily member 8 –2.4 (0.015)
Signaling and trafficking
   Npy1r Z18280 NPY-1 receptor 2.2 (0.015) 2.5 (0.014)
   Hcrt AF019566 Hypocretin 2.1 (0.002) 2.0 (0.001)
   Edn1 U35233 Endothelin 1 2.0 (0.002)
   Unc13 h1 AF115848 Unc13 homolog (C. elegans) 1 2.2 (0.005)
   Numb AV377244 Numb gene homolog (Drosophila) –2.4 (0.013)
   Cacna1g AJ012569 Calcium channel, voltage dependent, T type, α1G subunit 1.8 (0.034)
   Pld1 AA536939 Phospholipase D1 1.8 (0.033)
   Siat7d AJ007310 Sialytransferase 7D 2.1 (0.011) 2.3 (0.04)
   Catp AW046747 Cation-transporting ATPase 2.1 (0.008)
   Bet1 AF007552 Blocked early in transport 1 homolog (S. cerevisiae) 1.9 (0.035)
   Hbb-b1 J00413 Mouse β-globin major gene 2.0 (0.002)
   Anp32a U73478 Acidic nuclear phosphoprotein 32 2.1 (0.01)
   Timm10 AW122428 Translocase of inner mitochondrial membrane 10 homolog 1.9 (0.045)
Others
   Zfp354a L77247 Zinc finger protein 354A 1.8 (0.044)
   Nfix AA002843 Nuclear factor I/X –2.1 (0.01)
   Hs3st1 AF019385 Heparan sulfate (glucosamine) 3-O-sulfotransferase 1 2.6 (0.038)
   Pglyrp AV092014 Peptidoglycan recognition protein 1.9 (0.001)
   Col10a1 X67348 Type X collagen gene 2.3 (0.017) 1.9 (0.019)
   Myg1 Al842612 Melanocyte proliferating gene 1 1.8 (0.01)