TABLE 3

The expression of Bcrp, Mdr1a, Mrp1, Mrp4, and Oatp2 in brain homogenate

All mRNA levels were measured by real-time quantitative PCR and normalized by the concentration of HPRT. These were results from independent cDNA samples from three wild-type and Bcrp knockout mice, respectively (n = 3 ∼ 4, mean ± S.D., ratio to HRPT). BCRP KO and ND represent Bcrp knockout mice and not detected, respectively.




Bcrp

Mdr1a

Mrp1

Mrp4

Oatp2
Wild-type 18.1 ± 2.3 26.9 ± 5.9 17.4 ± 1.1 27.7 ± 2.2 40.8 ± 7.6
Bcrp KO
ND
28.4 ± 3.3
19.1 ± 7.6
26.9 ± 1.9
44.2 ± 7.2