TABLE 2

Vascular volume (Vvasc, microliters per gram of brain) of mouse brain in each experiment

Vascular volume was determined by coperfusion of [14C]sucrose for 2 min ([3H]DHEAS) or 1.5 min ([3H]mitoxantrone). Vascular volumes did not differ significantly between any of the experiments (p > 0.05, one-way ANOVA). Data are presented as the mean ± S.E. (n = 4 ∼ 10 per point).


Vascular Volume

Wild-Type Mice

Mdr1a/1b P-gp Knockout Mice

Bcrp Knockout Mice
Control
GF120918
Control
GF120918 (10 mg/kg)
Control
GF120918 (10 mg/kg)
10 mg/kg
20 mg/kg
μl/g brain
DHEAS 12.8 ± 1.2 16.9 ± 1.9 15.5 ± 0.8 11.3 ± 0.8 12.4 ± 0.5 11.3 ± 0.5 8.96 ± 1.26
Mitoxantrone
11.9 ± 2.6
11.3 ± 4.3

16.6 ± 1.8
16.7 ± 4.3
12.9 ± 1.3
13.0 ± 1.6