Final parameters from stepwise nonlinear least-squares regression analysis of [3H]DPDPE disposition in control and TR- IPLs in the presence or absence of GF120918 kuptake was fixed at 0.12 min-1, and Vperfusate was fixed at 88 ml for all conditions.
Vm,blefflux | Vm,blefflux | kbile | kbile | |
|---|---|---|---|---|
| nmol · min-1 | CV% | min-1 | CV% | |
| Control | 16 | 18 | 0.12 | 12 |
| TR- | 37 | 4 | 0.037 | 5 |
| Control + GF120918 | 0a | n/a | 0.14 | 21 |
| TR- + GF120918 | 19 | 21 | 0.0024 | 18 |
n/a, not applicable.
↵ a Model consistently converged at values approaching zero