Control Livers | TR- Livers | |||||
---|---|---|---|---|---|---|
-GF120918 | +GF120918 | -GF120918 | +GF120918 | |||
Mass excreted in bile (μmol) | 1.11 ± 0.05 | 1.26 ± 0.09 | 0.788 ± 0.057* | 0.148 ± 0.034† | ||
Perfusate clearance (ml/min)a | 7.34 ± 0.83 | 17.5 ± 1.7* | 7.68 ± 0.65 | 16.3 ± 0.9† | ||
Perfusate AUC0-Tlast (nmol · min/ml) | 213 ± 7 | 75 ± 6* | 356 ± 73* | 175 ± 27† | ||
Biliary clearanceperfusate→bile (ml/min)b | 5.22 ± 0.27 | 17.0 ± 0.7* | 2.27 ± 0.36* | 0.839 ± 0.095† | ||
Biliary clearanceliver→bile (ml/min)c | 1.89 ± 1.34 | 1.58 ± 0.62 | 0.216 ± 0.046* | 0.0203 ± 0.0061† |