GABA site ligands, P4S and THIP, evoked concentration-dependent decreases in FRET
Results are mean ± S.E.M. from four separate determinations.
Receptor Subtype | THIP | P4S | ||||
|---|---|---|---|---|---|---|
| EC50 | Maximum GABA | EC50 | Maximum GABA | |||
| μM | % | μM | % | |||
| α1β1γ2s | 43.7 ± 6.4 | 87 ± 5 | 8.7 ± 0.9 | 78 ± 4 | ||
| α1β2γ2s | 24.8 ± 1.6 | 94 ± 5 | 9.2 ± 0.5 | 84 ± 1 | ||
| α1β3γ2s | 26.1 ± 2.4 | 89 ± 7 | 11.7 ± 1.2 | 74 ± 2 | ||