Effect of donor compartment pH on permeability coefficients (Pam) of various compounds in the parallel artificial membrane permeability assay All compounds were incubated at 50 μM for 2 h at room temperature.
Test | Pam (cm/s) × 106 | ||
|---|---|---|---|
| Compound | pH 6.5a | pH 7.4a | |
| XP13512 | 0.65 | 0.095 | |
| Gabapentin | 0.02 | 0.026 | |
| Diltiazem | 7.0 | 31 | |
| Metoprolol | 0.018 | 0.16 | |
| Acyclovir | 0.02 | 0.02 | |
↵ a Indicates pH of the donor chamber