Permeability coefficients (Papp) for transepithelial transport of XP13512 or gabapentin across Caco-2 and MDCK monolayers Compounds were applied to the donor compartment at 100 to 200 μM and incubated for 1 h at 37°C.
Caco-2 | MDCK | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Test Compound | Papp (cm/s) × 106 | A to B/B to A ratio | Papp (cm/s) × 106 | A to B/B to A ratio | ||||||
| A to Ba | B to A | A to B | B to A | |||||||
| XP13512 | 31 | 5.7 | 5.4 | 35 | 11 | 3.2 | ||||
| Gabapentin | 3.2 | 3.4 | 0.94 | 0.73 | 0.25 | 2.9 | ||||
↵ a A, apical; B, basolateral