Stability of XP13512 sodium salt in tissues from different species All incubations were for 1 h at 37°C. The initial XP13512 concentration was 10 μM. All preparations contained 1 mg protein/ml.
Tissue Preparation | Rate of Conversion to Gabapentin | ||||||
|---|---|---|---|---|---|---|---|
| Sprague-Dawley Rat | Beagle Dog | Cynomolgus Monkey | Human | ||||
| pmol / min / mg protein | |||||||
| Plasma | 24.1 | NDa | 8.8 | 5.2 | |||
| Intestine | 189 | 99.2 | 184 | 196 | |||
| Lung | 88.6 | 86.9 | 107 | 68.5 | |||
| Liver | 125 | 136 | 140 | 146 | |||
| Kidney | 180 | 141 | 173 | 168 | |||
↵ a ND, not determined