IC50 values of GEM and GEM-1-O-glu on the OATP2-mediated uptake and metabolism of [14C]CERa
GEM | GEM-1-O-glu | ||
|---|---|---|---|
| μM | |||
| OATP2-mediated uptake | 72.4 ± 28.4 | 24.3 ± 19.8 | |
| CYP2C8-mediated metabolism | 28.0 ± 4.3 | 4.07 ± 1.23 | |
| CYP3A4-mediated metabolism | 372 ± 100 | 243 ± 59 | |
↵ a All data are represented as the mean ± computer-calculated S.D.