TABLE 3

Effects of menthol cigarette smoking on the disposition kinetics of continine

Values in parenthesis represent 95% CI.



Total Clearance

Renal CL

Nonrenal CL

T1/2

VSS

M
NM
M
NM
M
NM
M
NM
M
NM
ml/min ml/min ml/min min l
African-Americans 40.9 (34.1-47.8) 42.7 (29.8-55.6) 11.5 (7.6-15.4) 12.3 (9.0-15.6) 29.4 (20.2-38.7) 30.4 (18.0-42.7) 1043 (907-1179) 1160 (791-1529) 61 (50-72) 66 (52-79)
Whites 53.3 (31.8-74.9) 57.3 (33.5-81.2) 9.1 (5.9-12.4) 10.2 (7.1-13.3) 44.2 (24.9-63.5) 47.1 (25.0-69.2) 1036 (750-1322) 939 (611-1267) 68 (56-80) 65 (52-77)
All
47.1 (36.8-57.4)
50.0 (37.7-62.3)
10.3 (8.0-12.6)
11.3 (9.3-13.3)
36.8 (26.7-46.9)
38.7 (26.9-50.6)
1039 (905-1174)
1049 (830-1269)
64 (57-72)
65 (58-73)
  • M, menthol; NM, nonmenthol.